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I am Biochemist and Cell Biologist interested in connective tissue, particularly cartilage and bone. As a former lecturer of the topic, I am also excited in cell biology in general.


I have done my major research career in Kuopio, Finland, starting with my Master's thesis in 1985. In January 2015 I moved from the University of Eastern Finland to Umeå University. In September 2015 I also started as a part-time professor at Xi'an Jiaotong University in Xi'an, China


Cartilage Tissue Engineering
Stem Cell


Wang X, Ning Y, Poulet B, Huang R, Hu M, Li C, Zhou R, Lammi M, Guo X: Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis. Cell Death Dis 12(6): 551, 2021 [Pubmed] [Full text]

Lei J, Amhare AF, Wang L, Lv Y, Deng H, Gao H, Guo X, Han J, Lammi MJ: Proteomic analysis of knee cartilage reveals potential signaling pathways in pathological mechanism of Kashin-Beck disease compared with osteoarthritis. Sci Rep 10(1): 6824, 2020 [Pubmed] [Full text]

Wang X, Jin Z, Chen M, Duan D, Lammi MJ, Guo X, Chang Y: Inhibiting the aberrant activation of Wnt/b-catenin signaling by selenium supplementation ameliorates deoxynivalenol-induced toxicity and catabolism in chondrocytes. J Cell Physiol 235(5): 4435-4442, 2020 [Pubmed] [Full text]

Ning Y, Wang X, Lammi MJ, Guo X: Changes in the NF-KB signaling pathway in juvenile and adult patients with Kashin-Beck disease. Exp Cell Res 379(2):140-149, 2019 [Pubmed] [Full text]

Prittinen J, Ylärinne J, Piltti J, Karhula S, Rieppo L, Ojanen P, Korhonen RK, Saarakkala S, Lammi MJ, Qu C: Effect of centrifugal force on the development of articular neocartilage with bovine primary chondrocytes. Cell Tissue Res 375: 629-639, 2019 [Pubmed] [Full text]


Li W, Hirvasniemi J, Guo X, Saarakkala S, Lammi MJ, Qu C: Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee. Sci Rep 8: 17510, 2018 [Pubmed] [Full text]

Lammi MJ, Piltti J, Prittinen, Qu C: Challenges in fabrication of tissue-engineered cartilage with correct cellular colonization and extracellular matrix assembly. Int J Mol Sci 19: E2700, 2018 [Pubmed] [Full text]

Lammi MJ, Qu C: Selenium-related transcriptional regulation of gene expression. Int J Mol Sci 19: E 2665, 2018 [Pubmed] [Full text]

Ning Y, Wang X, Zhang P, Anatoly SV, Prakash NT, Li C, Zhou R, Lammi M, Zhang F, Guo X: Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. J Trace Elem Med Biol 50: 441-460, 2018 [Pubmed] [Full text]


Wang S, Yan R, Wang B, Du P, Tan W, Lammi MJ, Guo X: Prediction of co-expression genes and integrative analysis of gene microarray and proteomics profile of Keshan disease. Sci Rep 8: 231, 2018 [Pubmed] [Full text]


Wu C, Liu H, Zhang F, Shao W, Yang L, Ning Y, Wang S, Zhao G, Lee BJ, Lammi M, Guo X: Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease. Sci Rep 7: 17553, 2017 [Pubmed] [Full text]


Piltti J, Bygdell J, Fernandez-Echevarria C, Marcellino D, Lammi MJ: Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells. Sci Rep 7: 3708, 2017 [Pubmed] [Full text]

Last updated June 18, 2021

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